Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional …
D Qiu, G Zhao, Y Aoki, L Shi, A Uyei, S Nazarian… - Journal of biological …, 1999 - ASBMB
PG490 (triptolide) is a diterpene triepoxide with potent immunosuppressive and
antiinflammatory properties. PG490 inhibits interleukin (IL)-2 expression by normal human
peripheral blood lymphocytes stimulated with phorbol 12-myristate 13-acetate (PMA) and
antibody to CD3 (IC 50 of 10 ng/ml), and with PMA and ionomycin (Iono, IC 50 of 40 ng/ml).
In Jurkat T-cells, PG490 inhibits PMA/Iono-stimulated IL-2 transcription. PG490 inhibits the
induction of DNA binding activity at the purine-box/antigen receptor response element …
antiinflammatory properties. PG490 inhibits interleukin (IL)-2 expression by normal human
peripheral blood lymphocytes stimulated with phorbol 12-myristate 13-acetate (PMA) and
antibody to CD3 (IC 50 of 10 ng/ml), and with PMA and ionomycin (Iono, IC 50 of 40 ng/ml).
In Jurkat T-cells, PG490 inhibits PMA/Iono-stimulated IL-2 transcription. PG490 inhibits the
induction of DNA binding activity at the purine-box/antigen receptor response element …
