[HTML][HTML] Filaggrin-2 barrier protein inversely varies with skin inflammation
J Seykora, T Dentchev, DJ Margolis - Experimental dermatology, 2015 - ncbi.nlm.nih.gov
J Seykora, T Dentchev, DJ Margolis
Experimental dermatology, 2015•ncbi.nlm.nih.govBackground Atopic dermatitis (AD) is a common chronic, episodic inflammatory ailment 1.
Recent studies have shown that AD is a life-long disease that often begins in early
childhood and that persists into adulthood. AD is at least in part associated with a
dysfunctional skin barrier often due to loss of function (LOF) mutations of filaggrin (FLG). 2
Although the impact of FLG LOF on skin barrier function is less certain. 3 While mutations of
FLG are relatively common in Asian and European children with AD they were very …
Recent studies have shown that AD is a life-long disease that often begins in early
childhood and that persists into adulthood. AD is at least in part associated with a
dysfunctional skin barrier often due to loss of function (LOF) mutations of filaggrin (FLG). 2
Although the impact of FLG LOF on skin barrier function is less certain. 3 While mutations of
FLG are relatively common in Asian and European children with AD they were very …
Background
Atopic dermatitis (AD) is a common chronic, episodic inflammatory ailment 1. Recent studies have shown that AD is a life-long disease that often begins in early childhood and that persists into adulthood. AD is at least in part associated with a dysfunctional skin barrier often due to loss of function (LOF) mutations of filaggrin (FLG). 2 Although the impact of FLG LOF on skin barrier function is less certain. 3 While mutations of FLG are relatively common in Asian and European children with AD they were very infrequently found in those of African ancestry. 2; 4
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