[HTML][HTML] Acute hyperhidrosis and postural tachycardia in a COVID-19 patient

T Umapathi, MQW Poh, BE Fan, KFC Li… - Clinical Autonomic …, 2020 - Springer
T Umapathi, MQW Poh, BE Fan, KFC Li, J George, JYL Tan
Clinical Autonomic Research, 2020Springer
A 39-year-old man, a construction worker with no medical history, was diagnosed with
COVID-19 from nasopharyngeal swab reverse transcription polymerase chain reaction (rt-
PCR) when he presented with 8 days of acute respiratory symptoms, diarrhea, abdominal
discomfort and pneumonia. Within 2 days ‚he required supplemental oxygen and prone-
positioning, and was placed on a remdesivir trial. He recovered without ventilatory support.
His blood pressure at admission was 165/92 mmHg. In hospital ‚it ranged from 130 to …
A 39-year-old man, a construction worker with no medical history, was diagnosed with COVID-19 from nasopharyngeal swab reverse transcription polymerase chain reaction (rt-PCR) when he presented with 8 days of acute respiratory symptoms, diarrhea, abdominal discomfort and pneumonia. Within 2 days ‚he required supplemental oxygen and prone-positioning, and was placed on a remdesivir trial. He recovered without ventilatory support. His blood pressure at admission was 165/92 mmHg. In hospital ‚it ranged from 130 to 170/80–110 mmHg. He was started on amlodipine 2.5 mg. His blood glucose ranged from 9 to 13 mmol/L and HbA1c was 8.8%. He was diagnosed with diabetes mellitus (DM) and given insulin and metformin. At day 13 of illness, as he was recuperating in the general ward with stable blood pressure and parameters, he developed right leg ischemia. Computed tomography (CT) aortogram showed a mural thrombus at the suprarenal aorta.
Aortic tributaries were unobstructed. Infarcts were limited to the spleen and upper pole of the right kidney. The adrenal gland was normal in appearance. There was no thrombosis of the vena cava. He underwent embolectomy and endovascular repair. Duration of ischemia to reperfusion was approximately 26 h. After initial unfractionated heparin, he was given aspirin and warfarin. The raised factor VIII levels, von Willebrand factor antigen, fibrinogen, anti-cardiolipin antibodies and presence of lupus anticoagulant (Table 1) indicated a COVID-19-associated immuno-thrombotic state [1]. He was extubated the day after surgery and sent to the general ward 2 days later.
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