[HTML][HTML] Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathione
L Chen, RP Patel, X Teng, CA Bosworth… - Journal of biological …, 2006 - ASBMB
We investigated the mechanisms by which S-nitrosoglutathione (GSNO) alters cystic fibrosis
transmembrane conductance regulator (CFTR) mediated chloride (Cl–) secretion across
Calu-3 cells, an extensively used model of human airway gland serous cells. Confluent
monolayers of Calu-3 cells, grown under an air-liquid interface, were mounted in Ussing
chambers for the measurements of chloride short circuit current (I sc) and trans-epithelial
resistance (R t). Addition of GSNO into the apical compartment of these chambers resulted in …
transmembrane conductance regulator (CFTR) mediated chloride (Cl–) secretion across
Calu-3 cells, an extensively used model of human airway gland serous cells. Confluent
monolayers of Calu-3 cells, grown under an air-liquid interface, were mounted in Ussing
chambers for the measurements of chloride short circuit current (I sc) and trans-epithelial
resistance (R t). Addition of GSNO into the apical compartment of these chambers resulted in …
