Building a tissue-based molecular diagnostic system in heart transplant rejection: The heart Molecular Microscope Diagnostic (MMDx) System
Background The emergence of molecular systems offers opportunities for improving the
assessment of rejection in heart transplant biopsy specimens. The present study developed
a microarray-based system for assessing heart transplant endomyocardial biopsy (EMB)
specimens. Methods We analyzed 331 protocol or for-cause EMB specimens from 221
subjects in 3 centers (Edmonton, Bologna, and Paris). Unsupervised principal component
analysis (PCA) and archetype analysis used rejection-associated transcripts (RATs) shown …
assessment of rejection in heart transplant biopsy specimens. The present study developed
a microarray-based system for assessing heart transplant endomyocardial biopsy (EMB)
specimens. Methods We analyzed 331 protocol or for-cause EMB specimens from 221
subjects in 3 centers (Edmonton, Bologna, and Paris). Unsupervised principal component
analysis (PCA) and archetype analysis used rejection-associated transcripts (RATs) shown …
