Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice
M Horio, M Kohno, Y Fujita, T Ishima, R Inoue… - Neurochemistry …, 2011 - Elsevier
d-Serine, an endogenous co-agonist of the N-methyl-d-aspartate (NMDA) receptor, plays an
important role in mammalian brain neurotransmission, via the NMDA receptor. d-Serine is
synthesized from l-serine by the pyridoxal-5′ phosphate-dependent enzyme serine
racemase (SRR), and d-serine is metabolized by d-amino acid oxidase (DAAO). In this
study, we measured levels of the neurotransmission related amino acids, d-serine, l-serine,
glycine, glutamine and glutamate in the frontal cortex, hippocampus, striatum and …
important role in mammalian brain neurotransmission, via the NMDA receptor. d-Serine is
synthesized from l-serine by the pyridoxal-5′ phosphate-dependent enzyme serine
racemase (SRR), and d-serine is metabolized by d-amino acid oxidase (DAAO). In this
study, we measured levels of the neurotransmission related amino acids, d-serine, l-serine,
glycine, glutamine and glutamate in the frontal cortex, hippocampus, striatum and …
